nhaC [2017-8-11 16:0:3]

Na /H antiporter

locus: BSU09680

pI: 7.87

mw: 47.89 kDa

protein length: 453 aa

gene length: 1359 bp

function: pH homeostasis

product: Na /H antiporter

essential: no

synonyms: yheL

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.1|Metal ion homeostasis (K, Na, Ca, Mg)] → [category|SW 1.3.1.2|Sodium uptake/ export]
• [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.5|PH homeostasis]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 1,042,885 → 1,044,246

The protein

Protein family

• nhaC Na(+)/H(+) antiporter family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|49DF23B8E19658DB32835B6D23DD21E4BF481B20|MleN]

[SW|Localization]

• cell membrane (according to Swiss-Prot)

Expression and Regulation

Operons

• genes: [gene|A7F1B4C0D32E18773170BFBEEB94E5EF55C7DB97|nhaC]
  description: [Pubmed|21815947]

  regulatory mechanism

  • [protein|D0BBFE1706429A98B7E93998794061A112FE8ECA|NhaX]: activation, (probably) [Pubmed|11274110], in [regulon|D0BBFE1706429A98B7E93998794061A112FE8ECA|NhaX regulon]

  regulation

  • subject to indirect positive regulation by [protein|search|CodY] [Pubmed|24843172]

  additional information

  • the mRNA is substantially stabilized upon depletion of [gene|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [PubMed|21815947]

Biological materials

Mutant

• MGNA-A707 (yheL::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/707 NBRP B. subtilis, Japan]

References

Reviews

• 27935846

Original publications

• 11274110,21815947,24843172